In-cell chemical network driven by neo-PTMs
Research
Presentations
Dr. Yamatsugu gave an invited lecture in 創薬懇話会2024.
Research
Outline
Outline
Our research aims are 1) develop chemical methods to introducing artificial or hitherto unknown post-translational modifications (neo-PTMs) into proteins, 2) detect change of endogenous chemical network driven by the neo-PTMs, and 3) understand their biological outputs.
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About
A01
Chemical catalysts
Project leader／Dr. Kenzo Yamatsugu
A02
Synergistic effects
Principal Investigator／Dr. Yoshihiro Sohtome
A03
Biological outcomes
Principal Investigator／Dr. Tadahiro Shimazu
Publication
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Presentations
Dr. Yamatsugu gave an invited lecture in 創薬懇話会2024.
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Publications
Catalytic Aerobic Carbooxygenation for the Construction of Vicinal Tetrasubstituted Centers: Application to the Synthesis of Hexa-substituted g-Lactones
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Publications
In vivo-stable bis-iminobiotin for targeted radionuclide delivery with the mutant streptavidin